Synoxazolidinones A and B: Novel Bioactive Alkaloids from the Ascidian Synoicum pulmonaria

Bioassay-guided fractionation of the sub-Arctic ascidian Synoicum pulmonaria collected off the Norwegian coast led to the isolation of a novel family of brominated guanidinium oxazolidinones named synoxazolidinones A and B (1 and 2). The backbone of the compounds contains a 4-oxazolidinone ring rare...

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Published inOrganic letters Vol. 12; no. 21; pp. 4752 - 4755
Main Authors Tadesse, Margey, Strøm, Morten B, Svenson, Johan, Jaspars, Marcel, Milne, Bruce F, Tørfoss, Veronika, Andersen, Jeanette H, Hansen, Espen, Stensvåg, Klara, Haug, Tor
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 05.11.2010
Amer Chemical Soc
Subjects
Animals
Chemistry
Chemistry, Organic
Guanidine - analogs & derivatives
Guanidine - chemistry
Models, Molecular
Molecular Structure
Oxazolidinones - chemistry
Physical Sciences
Science & Technology
Urochordata - chemistry
ANTIBACTERIAL
ADAREANUM
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Summary:Bioassay-guided fractionation of the sub-Arctic ascidian Synoicum pulmonaria collected off the Norwegian coast led to the isolation of a novel family of brominated guanidinium oxazolidinones named synoxazolidinones A and B (1 and 2). The backbone of the compounds contains a 4-oxazolidinone ring rarely seen in natural products. The structure of the compounds was determined by spectroscopic methods. The synoxazolidinones exhibited antibacterial and antifungal activities.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol101707u