Dioxygen Activation under Ambient Conditions: Cu-Catalyzed Oxidative Amidation−Diketonization of Terminal Alkynes Leading to α-Ketoamides

A novel Cu-catalyzed oxidative amidation−diketonization reaction of terminal alkynes leading to α-ketoamides has been developed. This chemistry offers a valuable mechanistic insight into this novel Cu catalysis via a radical process. O2 not only participates as the ideal oxidant but also undergoes d...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 132; no. 1; pp. 28 - 29
Main Authors Zhang, Chun, Jiao, Ning
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 13.01.2010
Amer Chemical Soc
Subjects
Alkynes - chemistry
Amides - chemistry
Catalysis
Chemistry
Chemistry, Multidisciplinary
Copper - chemistry
Ketones - chemistry
Oxidation-Reduction
Oxygen - chemistry
Physical Sciences
Science & Technology
ALCOHOLS
SUPEROXIDE
OXIDANT
RADICALS
TEMPO
BOND
CYCLIZATION
AMINYL
MOLECULAR-OXYGEN
H ACTIVATION
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Summary:A novel Cu-catalyzed oxidative amidation−diketonization reaction of terminal alkynes leading to α-ketoamides has been developed. This chemistry offers a valuable mechanistic insight into this novel Cu catalysis via a radical process. O2 not only participates as the ideal oxidant but also undergoes dioxygen activation under ambient conditions in this transformation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0002-7863
1520-5126
DOI:10.1021/ja908911n