Simple Three-Component Method for the Synthesis of Spiroindeno[1,2-b]pyrido[2,3-d]pyrimidine-5,3′-indolines

• Published in: ACS combinatorial science Vol. 13; no. 1; pp. 96 - 99
• Main Authors: Imani Shakibaei, Ghazaleh, Feiz, Afsaneh, Reza Khavasi, Hamid, Abolhasani Soorki, Ali, Bazgir, Ayoob
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 10.01.2011; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Applied; Chemistry, Medicinal; Chemistry, Multidisciplinary; Indoles - chemical synthesis; Indoles - pharmacology; Life Sciences & Biomedicine; Microbial Sensitivity Tests; Models, Molecular; Pharmacology & Pharmacy; Physical Sciences; Science & Technology; isatins; amino uracils; spiroacenaphthylene-1,4'-indeno-1,5'-pyrido[2,3-d]pyrimidines; acenaphthylene-1,2-dione; catalyst-free; spiroindeno[1,2-b]pyrido[2,3-d]pyrimidine-5,3'-indolines; ONE-POT; EFFICIENT SYNTHESIS; LIBRARY; SPIROOXINDOLES; DIPYRIDAMOLE; spiroindeno[1,2-b]pyrido[2,3-d]pyrimidine-5,3 '-indolines; spiroacenaphthylene-1,4 '-indeno-1,5 '-pyrido[2,3-d]pyrimidines; BIOLOGICAL-ACTIVITY; AGENTS; INHIBITORS; DERIVATIVES
• ISSN: 2156-8952; 2156-8944
• DOI: 10.1021/co1000053

An efficient, simple, and catalyst-free synthesis of spiroindeno[1,2-b]pyrido[2,3-d]pyrimidine-5,3′-indolines and spiroacenaphthylene-1,4′-indeno-1,5′-pyrido[2,3-d]pyrimidines by the three-component reaction of 1,3-indandione, amino uracils and isatins or acenaphthylene-1,2-dione in refluxing ethanol is reported.