Circulating Human Monocytes in the Acute Coronary Syndrome Express a Characteristic Proteomic Profile

• Published in: Journal of proteome research Vol. 6; no. 2; pp. 876 - 886
• Main Authors: Barderas, María G, Tuñón, José, Dardé, Verónica M, De la Cuesta, Fernando, Durán, María C, Jiménez-Nácher, José J, Tarín, Nieves, López-Bescós, Lorenzo, Egido, Jesús, Vivanco, Fernando
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 01.02.2007
• Subjects: Aged; Blood Proteins - metabolism; Coronary Angiography; Coronary Disease - blood; Coronary Disease - diagnostic imaging; Enzymes - blood; Female; Humans; Male; Middle Aged; Monocytes - pathology; Patient Selection; Proteomics - methods; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

We examined the proteome of circulating monocytes of patients with acute coronary syndrome at different times in comparison to that of patients with stable coronary artery disease. On admission, the expression of 18 spot proteins was altered, 10 of which were totally absent. This pattern changed pro...