Circulating Human Monocytes in the Acute Coronary Syndrome Express a Characteristic Proteomic Profile

We examined the proteome of circulating monocytes of patients with acute coronary syndrome at different times in comparison to that of patients with stable coronary artery disease. On admission, the expression of 18 spot proteins was altered, 10 of which were totally absent. This pattern changed pro...

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Published inJournal of proteome research Vol. 6; no. 2; pp. 876 - 886
Main Authors Barderas, María G, Tuñón, José, Dardé, Verónica M, De la Cuesta, Fernando, Durán, María C, Jiménez-Nácher, José J, Tarín, Nieves, López-Bescós, Lorenzo, Egido, Jesús, Vivanco, Fernando
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 01.02.2007
Subjects
Aged
Blood Proteins - metabolism
Coronary Angiography
Coronary Disease - blood
Coronary Disease - diagnostic imaging
Enzymes - blood
Female
Humans
Male
Middle Aged
Monocytes - pathology
Patient Selection
Proteomics - methods
Spectrometry, Mass, Electrospray Ionization
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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Summary:We examined the proteome of circulating monocytes of patients with acute coronary syndrome at different times in comparison to that of patients with stable coronary artery disease. On admission, the expression of 18 spot proteins was altered, 10 of which were totally absent. This pattern changed progressively, and at 6 months, there were no differences with the monocyte proteome of stable patients. Keywords: acute coronary syndromes • monocytes • coronary artery disease • two-dimensional electrophoresis • mass spectrometry • atherosclerosis
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1535-3893
1535-3907
DOI:10.1021/pr0601990