Water-Soluble Green Perylenediimide (PDI) Dyes as Potential Sensitizers for Photodynamic Therapy

A series of water-soluble green perylenediimide (PDI) dyes have been synthesized. On red light excitation, these dyes were shown to be efficient generators of singlet oxygen, and in cell culture media, they were shown to display significant light-induced cytotoxic effects on the human erythroleukemi...

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Bibliographic Details
Published inOrganic letters Vol. 7; no. 14; pp. 2885 - 2887
Main Authors Yukruk, Funda, Dogan, A. Lale, Canpinar, Hande, Guc, Dicle, Akkaya, Engin U
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 07.07.2005
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Coloring Agents - chemistry
Coloring Agents - pharmacology
Humans
Molecular Structure
Perylene - chemistry
Perylene - pharmacology
Photochemotherapy
Photosensitizing Agents - chemistry
Photosensitizing Agents - pharmacology
Physical Sciences
Science & Technology
Singlet Oxygen - chemistry
Solubility
Tumor Cells, Cultured
Water - chemistry
SQUARAINE DYES
ACCEPTORS
CHROMOPHORES
BEHAVIOR
LIGHT
TEXAPHYRINS
PHTHALOCYANINES
NIR FLUORESCENT DYES
DERIVATIVES
CYTOTOXICITY
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Summary:A series of water-soluble green perylenediimide (PDI) dyes have been synthesized. On red light excitation, these dyes were shown to be efficient generators of singlet oxygen, and in cell culture media, they were shown to display significant light-induced cytotoxic effects on the human erythroleukemia cell line (K-562). It appears that highly versatile PDI dyes are likely to find new applications in photodynamic therapy.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol050841g