Fumimycin: A Peptide Deformylase Inhibitor with an Unusual Skeleton Produced by Aspergillus fumisynnematus
Fumimycin, an unusual metabolite incorporating an unusual alanine unit linked to a phenyl group at the α-carbon with both lactone and amide moieties, was isolated from cultures of Aspergillus fumisynnematus. Its structure was established by spectral analysis. Fumimycin was found to inhibit Staphyloc...
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Published in | Organic letters Vol. 9; no. 13; pp. 2449 - 2451 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
21.06.2007
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
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Summary: | Fumimycin, an unusual metabolite incorporating an unusual alanine unit linked to a phenyl group at the α-carbon with both lactone and amide moieties, was isolated from cultures of Aspergillus fumisynnematus. Its structure was established by spectral analysis. Fumimycin was found to inhibit Staphylococcus aureus peptide deformylase with an IC50 value of 4.1 μΜ and also showed antibacterial activity against S. aureus. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1523-7060 1523-7052 |
DOI: | 10.1021/ol0703231 |