Fumimycin:  A Peptide Deformylase Inhibitor with an Unusual Skeleton Produced by Aspergillus fumisynnematus

Fumimycin, an unusual metabolite incorporating an unusual alanine unit linked to a phenyl group at the α-carbon with both lactone and amide moieties, was isolated from cultures of Aspergillus fumisynnematus. Its structure was established by spectral analysis. Fumimycin was found to inhibit Staphyloc...

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Published inOrganic letters Vol. 9; no. 13; pp. 2449 - 2451
Main Authors Kwon, Yun-Ju, Sohn, Mi-Jin, Zheng, Chang-Ji, Kim, Won-Gon
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 21.06.2007
Amer Chemical Soc
Subjects
Amidohydrolases - antagonists & inhibitors
Aspergillus - chemistry
Aspergillus - metabolism
Benzofurans - chemistry
Benzofurans - metabolism
Benzofurans - pharmacology
Chemistry
Chemistry, Organic
Molecular Structure
Physical Sciences
Science & Technology
Staphylococcus aureus - enzymology
BACILLUS-SUBTILIS
ANTIBACTERIAL AGENTS
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Summary:Fumimycin, an unusual metabolite incorporating an unusual alanine unit linked to a phenyl group at the α-carbon with both lactone and amide moieties, was isolated from cultures of Aspergillus fumisynnematus. Its structure was established by spectral analysis. Fumimycin was found to inhibit Staphylococcus aureus peptide deformylase with an IC50 value of 4.1 μΜ and also showed antibacterial activity against S. aureus.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol0703231