Direct Lactone Formation by Using Hypervalent Iodine(III) Reagents with KBr via Selective C−H Abstraction Protocol

• Published in: Organic letters Vol. 9; no. 16; pp. 3129 - 3132
• Main Authors: Dohi, Toshifumi, Takenaga, Naoko, Goto, Akihiro, Maruyama, Akinobu, Kita, Yasuyuki
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 02.08.2007; Amer Chemical Soc
• Subjects: Benzoates - chemistry; Bromides - chemistry; Carboxylic Acids - chemistry; Chemistry; Chemistry, Organic; Indicators and Reagents; Iodine - chemistry; Lactones - chemical synthesis; Molecular Structure; Phthalimides - chemical synthesis; Physical Sciences; Potassium Compounds - chemistry; Science & Technology; ALCOHOLS; ORGANIC-SYNTHESIS; HYDROGEN; CLEAN OXIDATION; BIOLOGICAL-ACTIVITY; CHEMISTRY; ORGANOHYPERVALENT IODINE; GAMMA-LACTONES; DERIVATIVES; AROMATIC CARBOXYLIC-ACIDS

We have developed a new and reliable method for the direct construction of biologically important aryl lactones and phthalides from carboxylic and benzoic acids, using a combination of hypervalent iodine(III) reagents with KBr.