Direct Lactone Formation by Using Hypervalent Iodine(III) Reagents with KBr via Selective C−H Abstraction Protocol

We have developed a new and reliable method for the direct construction of biologically important aryl lactones and phthalides from carboxylic and benzoic acids, using a combination of hypervalent iodine(III) reagents with KBr.

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Bibliographic Details
Published inOrganic letters Vol. 9; no. 16; pp. 3129 - 3132
Main Authors Dohi, Toshifumi, Takenaga, Naoko, Goto, Akihiro, Maruyama, Akinobu, Kita, Yasuyuki
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 02.08.2007
Amer Chemical Soc
Subjects
Benzoates - chemistry
Bromides - chemistry
Carboxylic Acids - chemistry
Chemistry
Chemistry, Organic
Indicators and Reagents
Iodine - chemistry
Lactones - chemical synthesis
Molecular Structure
Phthalimides - chemical synthesis
Physical Sciences
Potassium Compounds - chemistry
Science & Technology
ALCOHOLS
ORGANIC-SYNTHESIS
HYDROGEN
CLEAN OXIDATION
BIOLOGICAL-ACTIVITY
CHEMISTRY
ORGANOHYPERVALENT IODINE
GAMMA-LACTONES
DERIVATIVES
AROMATIC CARBOXYLIC-ACIDS
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Summary:We have developed a new and reliable method for the direct construction of biologically important aryl lactones and phthalides from carboxylic and benzoic acids, using a combination of hypervalent iodine(III) reagents with KBr.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol071315n