Antiultraviolet, Antioxidant, and Antimicrobial Properties and Anticancer Potential of Novel Environmentally Friendly Amide-Modified Gallic Acid Derivatives

Polyphenols and amides isolated from natural products have various biological functions, such as antioxidant, antimicrobial, anticancer, and antiviral activities, and they are widely used in the fields of food and medicine. In this work, four novel and environmentally friendly amide-modified gallic...

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Bibliographic Details
Published inJournal of agricultural and food chemistry Vol. 71; no. 41; pp. 15352 - 15362
Main Authors Wang, Xuan, Cong, Jinyue, Zhang, Linghui, Han, Zhicheng, Jiang, Xiaohui, Yu, Liangmin
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 18.10.2023
Amer Chemical Soc
Subjects
Agriculture
Agriculture, Multidisciplinary
Chemistry
Chemistry, Applied
Food Science & Technology
Functional Structure/Activity Relationships
Life Sciences & Biomedicine
Physical Sciences
Science & Technology
anti-UV
healthy product
antimicrobial
antioxidant
gallic acid
anticancer
NANOPARTICLES
APOPTOSIS
ANTIBACTERIAL ACTIVITY
EXTRACTS
CYTOTOXICITY
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Summary:Polyphenols and amides isolated from natural products have various biological functions, such as antioxidant, antimicrobial, anticancer, and antiviral activities, and they are widely used in the fields of food and medicine. In this work, four novel and environmentally friendly amide-modified gallic acid derivatives (AMGADs), which were prepared by using different amides to modify gallic acid (GA) from Polygonaceae plants, displayed good antiultraviolet (anti-UV), antioxidant, antimicrobial, and anticancer effects. Significantly, the anti-UV capability of compounds n1 and n2 was notably superior to that of the UV absorber GA. Moreover, compound n2 possessed better 2,2-diphenyl-1-picrylhydrazyl radical (DPPH•) scavenging ability and ferric reducing antioxidant power than vitamin C. The antibacterial activities of all AMGADs, with inhibition rates of more than 96.00 and 79.00% for Escherichia coli and Staphylococcus aureus, respectively, were better than those of GA. Compound n1 had broad-spectrum anticancer activity, and its inhibitory effect on HepG2 cells exceeded that of 5-fluorouracil. The good and rich bioactivities of these AMGADs revealed that combining GA with amides is conducive to improving the activity of GA, and this study laid a good foundation for their scientific application in the fields of food and medicine.
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ISSN:0021-8561
1520-5118
DOI:10.1021/acs.jafc.3c04096