Preparation of Alkylidene Indane and Related Scaffolds and Their Further Elaboration to Novel Chemotypes

Alkylidene indane and ring-expanded scaffolds have been prepared using an enantioselective crotylation/Heck cyclization sequence. Further diversification using consecutive cyclopropanation−Cope rearrangement affords novel chemotypes including spiroindane frameworks.

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Bibliographic Details
Published inOrganic letters Vol. 9; no. 25; pp. 5203 - 5206
Main Authors Kesavan, Sarathy, Panek, James S, Porco, John A
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 06.12.2007
Amer Chemical Soc
Subjects
Alkylation
Azo Compounds - chemical synthesis
Azo Compounds - chemistry
Chemistry
Chemistry, Organic
Cyclization
Indans - chemical synthesis
Indans - chemistry
Indans - classification
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Structure
Physical Sciences
Science & Technology
Spiro Compounds - chemical synthesis
Spiro Compounds - chemistry
Stereoisomerism
Vinyl Compounds - chemical synthesis
Vinyl Compounds - chemistry
REARRANGEMENT
DIVERSITY-ORIENTED SYNTHESIS
CROTYLATION
CONSTRUCTION
CHEMISTRY
LIBRARY
SKELETAL DIVERSITY
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Summary:Alkylidene indane and ring-expanded scaffolds have been prepared using an enantioselective crotylation/Heck cyclization sequence. Further diversification using consecutive cyclopropanation−Cope rearrangement affords novel chemotypes including spiroindane frameworks.
Bibliography:Medline
NIH RePORTER
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol7023778