Highly Ortho-Selective Cross-Coupling of Dichlorobenzene Derivatives with Grignard Reagents

Highly ortho-selective cross-coupling of dichlorobenzene derivatives with Grignard reagents was realized using a combination of Pd2(dba)3 and PCy3. Use of hydroxylated terphenylphosphines further improved the reactions of dichlorophenol and dichloroaniline.

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Bibliographic Details
Published inOrganic letters Vol. 9; no. 26; pp. 5593 - 5595
Main Authors Ishikawa, Shunpei, Manabe, Kei
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 20.12.2007
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ACTIVATION
AMINATION
ARYLATION
CHLORIDES
ARYL
VINYL HALIDES
ARYLBORONIC ACIDS
CATALYSTS
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Summary:Highly ortho-selective cross-coupling of dichlorobenzene derivatives with Grignard reagents was realized using a combination of Pd2(dba)3 and PCy3. Use of hydroxylated terphenylphosphines further improved the reactions of dichlorophenol and dichloroaniline.
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol702646s