Convenient Synthesis of Photoaffinity Probes and Evaluation of Their Labeling Abilities

Convenient synthesis of a variety of photoaffinity probes was accomplished by utilizing our Ns strategy and novel resin. The synthetic probes were evaluated via the labeling ability with the preseniline 1 C-terminal fragments, which was identified as a therapeutic target for Alzheimer's disease...

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Published inOrganic letters Vol. 9; no. 11; pp. 2055 - 2058
Main Authors Kan, Toshiyuki, Kita, Yoichi, Morohashi, Yuichi, Tominari, Yusuke, Hosoda, Shinnosuke, Tomita, Taisuke, Natsugari, Hideaki, Iwatsubo, Takeshi, Fukuyama, Tohru
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 24.05.2007
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Molecular Structure
Photoaffinity Labels - analysis
Photoaffinity Labels - chemical synthesis
Photoaffinity Labels - chemistry
Physical Sciences
Presenilin-1 - chemistry
Science & Technology
PRESENILIN
ESTER
PEPTIDES
HIGHLY VERSATILE SYNTHESIS
BIOTIN
GAMMA-SECRETASE INHIBITORS
POLYAMINE TOXIN HO-416B
PROTEINS
SECONDARY-AMINES
STRATEGIES
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Summary:Convenient synthesis of a variety of photoaffinity probes was accomplished by utilizing our Ns strategy and novel resin. The synthetic probes were evaluated via the labeling ability with the preseniline 1 C-terminal fragments, which was identified as a therapeutic target for Alzheimer's disease.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol070376i