Improvement of Metabolic Syndrome in High-Fat Diet-Induced Mice by Yeast β‑Glucan Is Linked to Inhibited Proliferation of Lactobacillus and Lactococcus in Gut Microbiota

• Published in: Journal of agricultural and food chemistry Vol. 69; no. 27; pp. 7581 - 7592
• Main Authors: Chen, Guijie, Chen, Dan, Zhou, Wangting, Peng, Yujia, Chen, Chunxu, Shen, Wenbiao, Zeng, Xiaoxiong, Yuan, Qingxia
• Format: Journal Article
• Language: English
• Published: American Chemical Society 14.07.2021
• Subjects: Bioactive Constituents, Metabolites, and Functions; metabolic syndrome; gut microbiota; yeast β-glucan; high-fat diet
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/acs.jafc.1c00866

There is growing evidence that prevention of metabolic syndrome (MS) by dietary fibers is intricately linked to gut microbiota. In the present work, the mice were fed a high-fat diet (HFD) and orally treated with yeast β-glucan to further examine the effects of β-glucan on MS and gut microbiota and the potential relationship between gut microbiota and its activity. After intervention for 10 weeks, it was found that the treatment of yeast β-glucan could significantly improve the HFD-induced MS. Furthermore, pro-inflammatory cytokines in plasma including IL-6 and IL-1β were decreased. Yeast β-glucan could regulate the diversity and composition of HFD-induced gut microbiota. Moreover, the relative abundances of Lactobacillus and Lactococcus, having significant positive correlation with metabolic changes, were decreased by β-glucan, which might play a critical role in attenuation of MS. Our findings suggest that yeast β-glucan shows promising application as a prebiotic for preventing MS and regulating gut microbiota.