A Novel Convenient Synthesis of Benzoquinazolines

A novel synthetic pathway to benzoquinazolines from naphthylamines is reported. Benzoquinazoline nucleus was cyclized in good yield from N-protected naphthylamines using hexamethylenetetramine in TFA and potassium ferricyanide in aqueous ethanolic KOH. This method is efficient and convenient with re...

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Bibliographic Details
Published inOrganic letters Vol. 8; no. 2; pp. 255 - 256
Main Authors Marzaro, Giovanni, Chilin, Adriana, Pastorini, Giovanni, Guiotto, Adriano
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 19.01.2006
Amer Chemical Soc
Subjects
2-Naphthylamine - analogs & derivatives
2-Naphthylamine - chemistry
Benzene Derivatives - chemical synthesis
Catalysis
Chemistry
Chemistry, Organic
Cyclization
Indicators and Reagents
Molecular Structure
Physical Sciences
Quinazolines - chemical synthesis
Science & Technology
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Summary:A novel synthetic pathway to benzoquinazolines from naphthylamines is reported. Benzoquinazoline nucleus was cyclized in good yield from N-protected naphthylamines using hexamethylenetetramine in TFA and potassium ferricyanide in aqueous ethanolic KOH. This method is efficient and convenient with respect to previously reported synthetic pathways.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol052594m