1,1,1-Tris(hydroxymethyl)ethane as a New, Efficient, and Versatile Tripod Ligand for Copper-Catalyzed Cross-Coupling Reactions of Aryl Iodides with Amides, Thiols, and Phenols

1,1,1-Tris(hydroxymethyl)ethane was presented as a new, efficient, and versatile tridentate O-donor ligand suitable for the copper-catalyzed formation of C−N, C−S, and C−O bonds. This inexpensive and commercially available tripod ligand has been demonstrated to facilitate the copper-catalyzed cross-...

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Bibliographic Details
Published inOrganic letters Vol. 8; no. 24; pp. 5609 - 5612
Main Authors Chen, Yao-Jung, Chen, Hsin-Hung
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 23.11.2006
Amer Chemical Soc
Subjects
Alkanes - chemistry
Amides - chemistry
Catalysis
Chemistry
Chemistry, Organic
Copper - chemistry
Indicators and Reagents
Iodides - chemistry
Ligands
Phenols - chemistry
Physical Sciences
Science & Technology
Sulfhydryl Compounds - chemistry
HALIDES
AMINATION
C-O BOND
AMIDATION
NITROGEN
ALKYLAMINES
N-ARYLATION
BROMIDES
HIGHLY EFFICIENT
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Summary:1,1,1-Tris(hydroxymethyl)ethane was presented as a new, efficient, and versatile tridentate O-donor ligand suitable for the copper-catalyzed formation of C−N, C−S, and C−O bonds. This inexpensive and commercially available tripod ligand has been demonstrated to facilitate the copper-catalyzed cross-coupling reactions of aryl iodides with amides, thiols, and phenols to afford the corresponding desired products in good to excellent yields.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol062339h