Antimalarial activity of the bisquinoline trans-N1,N2-bis (7-chloroquinolin-4-yl)cyclohexane-1,2-diamine: comparison of two stereoisomers and detailed evaluation of the S,S enantiomer, Ro 47-7737

• Published in: Antimicrobial Agents and Chemotherapy Vol. 41; no. 3; pp. 677 - 686
• Main Authors: RIDLEY, R. G, MATILE, H, GUENZI, A, URWYLER, H, GOCKE, E, POTTHAST, J.-M, CSATO, M, THOMAS, A, PETERS, W, JAQUET, C, DORN, A, HOFHEINZ, W, LEUPIN, W, MASCIADRI, R, THEIL, F.-P, RICHTER, W. F, GIROMETTA, M.-A
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.03.1997
• Subjects: Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antimalarials; Antimalarials - pharmacokinetics; Antimalarials - pharmacology; Antimalarials - therapeutic use; Antiparasitic agents; Biological and medical sciences; Chloroquine - pharmacology; Comparative Study; Cyclohexylamines; Cyclohexylamines - pharmacokinetics; Cyclohexylamines - pharmacology; Cyclohexylamines - therapeutic use; Dogs; Drug Resistance; Half-Life; Heme - biosynthesis; Malaria, Vivax - drug therapy; Malaria, Vivax - parasitology; Malaria, Vivax - prevention & control; Male; Medical sciences; Mice; Pharmacology. Drug treatments; Plasmodium falciparum - drug effects; Plasmodium vivax - drug effects; Quinolines; Quinolines - pharmacokinetics; Quinolines - pharmacology; Quinolines - therapeutic use; Rats; Rats, Wistar; Stereoisomerism; Antimalarial; Drug susceptibility test; Chloroquine; Prevention; Plasmodium falciparum; Plasmodium vivax; Plasmodium berghei; Enantiomer; Parasiticid; Activity spectrum; Mechanism of action; Protozoa; Mefloquine; Rodentia; Oral administration; Biological activity; Infection; Resistance; Vertebrata; Chemotherapy; Experimental disease; Mammalia; Treatment; Mouse; Animal; Racemate; Effective dose; Pharmacokinetics; Sporozoa; Comparative study
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.41.3.677

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