Identification of an Activator of the Retinoid X Receptor

• Published in: Journal of natural products (Washington, D.C.) Vol. 57; no. 10; pp. 1458 - 1461
• Main Authors: Pathirana, Charles, Heyman, Richard A, Lazarchik, Steven B
• Format: Journal Article
• Language: English
• Published: CINCINNATI American Chemical Society 01.10.1994; AMER SOC PHARMACOGNOSY
• Subjects: Animals; Carbohydrate Sequence; Cells, Cultured; Chemistry, Medicinal; Drosophila melanogaster - chemistry; Glucosides - isolation & purification; Glucosides - pharmacology; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Pharmacology & Pharmacy; Plant Sciences; Receptors, Retinoic Acid - drug effects; Retinoid X Receptors; Science & Technology; Spectroscopy, Fourier Transform Infrared; Transcription Factors - drug effects; Tretinoin - analogs & derivatives; Tretinoin - isolation & purification; Tretinoin - pharmacology; ACID; NUCLEAR RECEPTOR

A metabolite of all-trans retinoic acid produced by insect cells was discovered to activate the intracellular retinoic acid X receptor. The compound, beta-glucopyranosyl 9-cis-retinoate [1], was purified and its structure was determined by analysis of spectroscopic data.