Identification of an Activator of the Retinoid X Receptor

A metabolite of all-trans retinoic acid produced by insect cells was discovered to activate the intracellular retinoic acid X receptor. The compound, beta-glucopyranosyl 9-cis-retinoate [1], was purified and its structure was determined by analysis of spectroscopic data.

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Bibliographic Details
Published inJournal of natural products (Washington, D.C.) Vol. 57; no. 10; pp. 1458 - 1461
Main Authors Pathirana, Charles, Heyman, Richard A, Lazarchik, Steven B
Format Journal Article
LanguageEnglish
Published CINCINNATI American Chemical Society 01.10.1994
AMER SOC PHARMACOGNOSY
Subjects
Animals
Carbohydrate Sequence
Cells, Cultured
Chemistry, Medicinal
Drosophila melanogaster - chemistry
Glucosides - isolation & purification
Glucosides - pharmacology
Life Sciences & Biomedicine
Magnetic Resonance Spectroscopy
Molecular Sequence Data
Molecular Structure
Pharmacology & Pharmacy
Plant Sciences
Receptors, Retinoic Acid - drug effects
Retinoid X Receptors
Science & Technology
Spectroscopy, Fourier Transform Infrared
Transcription Factors - drug effects
Tretinoin - analogs & derivatives
Tretinoin - isolation & purification
Tretinoin - pharmacology
ACID
NUCLEAR RECEPTOR
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Summary:A metabolite of all-trans retinoic acid produced by insect cells was discovered to activate the intracellular retinoic acid X receptor. The compound, beta-glucopyranosyl 9-cis-retinoate [1], was purified and its structure was determined by analysis of spectroscopic data.
Bibliography:ark:/67375/TPS-75M7SZDJ-1
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ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0163-3864
1520-6025
DOI:10.1021/np50112a020