An Efficient, Clean, and Catalyst-Free Synthesis of Fused Pyrimidines Using Sonochemistry

In this report, synthesis of indenopyrido[2,3-d]pyrimidine and pyrimido[4,5-b]quinoline derivatives was investigated via one-pot three-component reaction between 6-amino-2-(alkylthio)-pyrimidin-4(3H)one, 1,3-indanedione, or 1,3-cyclohexadione and arylaldehyde under ultrasonic irradiation in ethylene...

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Bibliographic Details
Published inOrganic chemistry International Vol. 2014; pp. 1 - 9
Main Authors Mamaghani, M., Tabatabaeian, K., Araghi, R., Fallah, A., Hossein Nia, R.
Format Journal Article
LanguageEnglish
Published New York Hindawi Publishing Corporation 01.01.2014
Hindawi Limited
Subjects
Chemistry
Colleges & universities
Solvents
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Summary:In this report, synthesis of indenopyrido[2,3-d]pyrimidine and pyrimido[4,5-b]quinoline derivatives was investigated via one-pot three-component reaction between 6-amino-2-(alkylthio)-pyrimidin-4(3H)one, 1,3-indanedione, or 1,3-cyclohexadione and arylaldehyde under ultrasonic irradiation in ethylene glycol as solvent at 65°C. In these reactions fused pyrimidine derivatives were synthesized with high to excellent yields (82–97%) and short reaction times (10–33 min).
ISSN:2090-200X
2090-2018
DOI:10.1155/2014/406869