Controlling Mode Selectivity in Palladium-Catalyzed Bisdiene Carbocyclizations:  Optimizing for Cyclization-Trapping over Cycloisomerization

Screening combinations of five catalyst precursors with 13 phosphorus ligands identified cyclization catalysts that favor carbocyclization-trapping with N-hydroxyphthalimide over a competing cycloisomerization mode.

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Bibliographic Details
Published inOrganic letters Vol. 5; no. 20; pp. 3595 - 3598
Main Authors Takacs, James M, Schroeder, Scott D, Han, Jianxin, Gifford, Meg, Jiang, Xun-tian, Saleh, Twana, Vayalakkada, Suresh, Yap, Amy H
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 02.10.2003
Amer Chemical Soc
Subjects
Alkenes - chemistry
Catalysis
Chemistry
Chemistry, Organic
Crystallography, X-Ray
Cyclization
Hydrocarbons, Cyclic - chemical synthesis
Hydrocarbons, Cyclic - chemistry
Indicators and Reagents
Isomerism
Molecular Structure
Palladium - chemistry
Phthalimides - chemistry
Physical Sciences
Science & Technology
ALCOHOLS
TELOMERIZATION
BUTADIENE
METHANOL
1,3-BUTADIENE
COMPLEXES
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Summary:Screening combinations of five catalyst precursors with 13 phosphorus ligands identified cyclization catalysts that favor carbocyclization-trapping with N-hydroxyphthalimide over a competing cycloisomerization mode.
Bibliography:Medline
NIH RePORTER
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SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol035253m