Selective Cleavage of Cbz-Protected Amines

Under conditions of catalytic Ni(0) and in most cases just over 1 equiv of Me2NH·BH3/K2CO3 or Cs2CO3, a Cbz-protected nitrogen, which is part of a heteroaromatic ring, can be chemospecifically cleaved without affecting a Cbz group on an originally basic amine.

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Bibliographic Details
Published inOrganic letters Vol. 3; no. 26; pp. 4145 - 4148
Main Authors Lipshutz, Bruce H, Pfeiffer, Steven S, Reed, Anthony B
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 27.12.2001
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
OXYGEN
DEPROTECTION
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Summary:Under conditions of catalytic Ni(0) and in most cases just over 1 equiv of Me2NH·BH3/K2CO3 or Cs2CO3, a Cbz-protected nitrogen, which is part of a heteroaromatic ring, can be chemospecifically cleaved without affecting a Cbz group on an originally basic amine.
Bibliography:ObjectType-Article-1
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol016693l