Tricyclic Quinoxalinediones: 5,6-Dihydro-1H-pyrrolo[1,2,3-de]quinoxaline-2,3-diones and 6,7-Dihydro-1H,5H-pyrido[1,2,3-de]quinoxaline-2,3-diones as Potent Antagonists for the Glycine Binding Site of the NMDA Receptor

• Published in: Journal of medicinal chemistry Vol. 37; no. 23; pp. 3956 - 3968
• Main Authors: Nagata, Ryu, Tanno, Norihiko, Kodo, Toru, Ae, Nobuyuki, Yamaguchi, Hiroshi, Nishimura, Tamiki, Antoku, Fujio, Tatsuno, Tohru, Kato, Terufumi
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.11.1994
• Subjects: Biological and medical sciences; Chemistry; Exact sciences and technology; Heterocyclic compounds; Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings; Medical sciences; Neuropharmacology; Neuroprotective agent; Organic chemistry; Pharmacology. Drug treatments; Preparations and properties; Quinoxaline derivatives; Rat; Angular nitrogen heterocycle; Rodentia; Neuroprotective agent; Glutamate receptor; Binding site; Tricyclic compound; Glycine; Biological activity; Vertebrata; Biological fixation; Mammalia; Mouse; Animal; Affinity; Antagonist; NMDA receptor; Chemical synthesis
• ISSN: 0022-2623; 1520-4804
• DOI: 10.1021/jm00049a015