Inter- and Intramolecular Reductive Coupling Reactions:  An Approach to the Phorbol Skeleton

An expeditious convergent route to the ABC-tricyclic core of the phorbol esters is described. The chemistry capitalizes upon both inter- and intramolecular reductive coupling processes promoted electrochemically and via the use of samarium diiodide.

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Bibliographic Details
Published inOrganic letters Vol. 2; no. 18; pp. 2873 - 2876
Main Authors Carroll, Georgia Law, Little, R. Daniel
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 07.09.2000
Amer Chemical Soc
Subjects
Carcinogens - chemical synthesis
Chemistry
Chemistry, Organic
Phorbol Esters - chemical synthesis
Physical Sciences
Science & Technology
Stereoisomerism
TUMOR PROMOTERS
ELECTROREDUCTIVE CYCLIZATION
FACILE SYNTHESIS
ANALOGS
ESTERS
SAMARIUM(II) DI-IODIDE
DITERPENE
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Summary:An expeditious convergent route to the ABC-tricyclic core of the phorbol esters is described. The chemistry capitalizes upon both inter- and intramolecular reductive coupling processes promoted electrochemically and via the use of samarium diiodide.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol006301v