Synthesis of Polysubstituted 4-Fluoroquinolinones

A convenient one-pot synthesis of 4-fluoroquinolinones that are active against KDR kinase is described. The mechanism of the reaction is believed to involve the formation of a quinone methide intermediate.

Saved in:
Bibliographic Details
Published inOrganic letters Vol. 6; no. 22; pp. 4061 - 4063
Main Authors Kiselyov, Alexander S, Piatnitski, Evgueni L, Doody, Jacqueline
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 28.10.2004
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
TYROSINE KINASE INHIBITORS
ROUTE
ACTIVATED TRIFLUOROMETHYL GROUP
NAPHTHALENES
FLUORO
SYNTHON
CYCLIZATION
Online AccessGet full text

Cover

More Information
Summary:A convenient one-pot synthesis of 4-fluoroquinolinones that are active against KDR kinase is described. The mechanism of the reaction is believed to involve the formation of a quinone methide intermediate.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol048257f