Total Synthesis of the Mycolactones

The first total synthesis of the mycolactones is reported. This work unambiguously confirms our earlier relative and absolute stereochemical assignment of the mycolactones.

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Bibliographic Details
Published inOrganic letters Vol. 4; no. 4; pp. 647 - 650
Main Authors Song, Fengbin, Fidanze, Steve, Benowitz, Andrew B, Kishi, Yoshito
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 21.02.2002
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Indicators and Reagents
Lactones - chemical synthesis
Lactones - chemistry
Macrolides
Magnetic Resonance Spectroscopy
Molecular Conformation
Mycobacterium ulcerans - chemistry
Physical Sciences
Science & Technology
TOXIN
ASYMMETRIC DIHYDROXYLATION
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Summary:The first total synthesis of the mycolactones is reported. This work unambiguously confirms our earlier relative and absolute stereochemical assignment of the mycolactones.
Bibliography:Medline
NIH RePORTER
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0172828