All-in-One Nanohybrids Combining Sonodynamic Photodynamic and Photothermal Therapies

• Published in: ACS applied materials & interfaces Vol. 16; no. 33; pp. 43387 - 43399
• Main Authors: Taydas, Dilsad, Özler, Muhammed Emre, Ergül, Mustafa, Şahin İnan, Zeynep Deniz, Sözmen, Fazlı
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 21.08.2024
• Subjects: Animals; Biological and Medical Applications of Materials and Interfaces; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Breast Neoplasms - therapy; Cell Line, Tumor; Copper - chemistry; Copper - pharmacology; Female; Gold - chemistry; Humans; Nanostructures - chemistry; Nanostructures - therapeutic use; Photochemotherapy; Photosensitizing Agents - chemical synthesis; Photosensitizing Agents - chemistry; Photosensitizing Agents - pharmacology; Photosensitizing Agents - therapeutic use; Photothermal Therapy; Protoporphyrins - chemistry; Protoporphyrins - pharmacology; Protoporphyrins - therapeutic use; Sulfides - chemistry; Sulfides - pharmacology; Ultrasonic Therapy - methods; thermosensitive polymer; sonodynamic therapy; photodynamic therapy; hollow nanohybrids; photothermal therapy
• ISSN: 1944-8244; 1944-8252; 1944-8252
• DOI: 10.1021/acsami.4c09715

A wide variety of methods are being developed to ultimately defeat cancer; while some of these strategies have shown highly positive results, there are serious obstacles to overcome to completely eradicate this disease. So, it is crucial to construct multifunctional nanostructures possessing intelligent capabilities that can be utilized to treat cancer. A possible strategy for producing these multifunctional nanostructures is to combine various cancer treatment techniques. Based on this point of view, we successfully synthesized multifunctional HCuS@Cu2S@Au–P­(NIPAM-co-AAm)-PpIX nanohybrids. The peculiarities of these thermosensitive polymer-modified and protoporphyrin IX (PpIX)-loaded hollow nanohybrids are that they combine photodynamic therapy (PDT), sonodynamic therapy (SDT), and photothermal therapy (PTT) with an intelligent design. As an all-in-one nanohybrids, HCuS@Cu2S@Au–P­(NIPAM-co-AAm)-PpIX nanohybrids were employed in the SDT–PDT–PTT combination therapy, which proved to have a synergistic therapeutic effect for in vitro tumor treatments against breast tumors.