Hydrogen Transfer Coupling with 100% Atom Economy: Synthesis of 2‑Indolyltetrahydronaphthyridine Derivatives

An iridium-catalyzed hydrogen transfer strategy, enabling straightforward access to tetrahydropyridine derivatives from aryl-1,8-naphthyridines and indolines was developed. This method has unprecedented advantages, including high step economy. In addition, it does not produce any byproducts or requi...

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Bibliographic Details
Published inJournal of organic chemistry Vol. 87; no. 18; pp. 12257 - 12264
Main Authors Zeng, Zheng, Deng, Yiqiu, Li, Lanyu, Li, Chungang, Zhong, Mingli
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 16.09.2022
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
HETEROARENES
AMINATION
HETEROCYCLES
IRIDIUM
AMINES
IMINES
COMPLEXES
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Summary:An iridium-catalyzed hydrogen transfer strategy, enabling straightforward access to tetrahydropyridine derivatives from aryl-1,8-naphthyridines and indolines was developed. This method has unprecedented advantages, including high step economy. In addition, it does not produce any byproducts or require an external high-pressure H2 gas source. The method offers an important platform for the transformation of 1,8-naphthyridines and indolines into functionalized products.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.2c01436