Characterization of the pJB12 Plasmid from Pseudomonas aeruginosa Reveals Tn6352, a Novel Putative Transposon Associated with Mobilization of the blaVIM-2-Harboring In58 Integron
The blaVIM-2-carrying In58 integron has been linked to a chromosomal location in different bacterial species, including Pseudomonas aeruginosa. This work reports the first fully sequenced In58-harboring plasmid, which is significantly different from the two previously identified blaVIM-2-carrying pl...
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Published in | Antimicrobial agents and chemotherapy Vol. 61; no. 5 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
1752 N St., N.W., Washington, DC
American Society for Microbiology
01.05.2017
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Subjects | |
Online Access | Get full text |
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Summary: | The blaVIM-2-carrying In58 integron has been linked to a chromosomal location in different bacterial species, including Pseudomonas aeruginosa. This work reports the first fully sequenced In58-harboring plasmid, which is significantly different from the two previously identified blaVIM-2-carrying plasmids in P. aeruginosa. blaVIM-2 might have been acquired by transposition of Tn6352, a novel transposon composed of the In58 and ISPa17 elements. The recognition of similar inverted repeat (IR) sites by ISPa17 reveals a common mobilization process associated with acquisition of the blaVIM-2 and blaVIM-1 genes. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Citation Botelho J, Grosso F, Peixe L. 2017. Characterization of the pJB12 plasmid from Pseudomonas aeruginosa reveals Tn6352, a novel putative transposon associated with mobilization of the blaVIM-2-harboring In58 integron. Antimicrob Agents Chemother 61:e02532-16. https://doi.org/10.1128/AAC.02532-16. |
ISSN: | 0066-4804 1098-6596 |
DOI: | 10.1128/AAC.02532-16 |