Last Observation Carried Forward Versus Mixed Models in the Analysis of Psychiatric Clinical Trials

[...] to LOCF, which assumes that subjects' responses after dropout would remain constant, these models can allow for estimation of subjects' responses after dropout using data prior to the dropout. [...] they use all the data and can reduce bias due to dropout. Because of the flexibility...

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Bibliographic Details
Published inThe American journal of psychiatry Vol. 166; no. 6; pp. 639 - 641
Main Authors Hamer, Robert M., Simpson, Pippa M.
Format Journal Article
LanguageEnglish
Published United States American Psychiatric Association 01.06.2009
Subjects
Clinical trials
Humans
Mathematical Computing
Mental Disorders - epidemiology
Methods
Patient Dropouts - statistics & numerical data
Randomized Controlled Trials as Topic
Sensitivity analysis
Statistics as Topic
Studies
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Summary:[...] to LOCF, which assumes that subjects' responses after dropout would remain constant, these models can allow for estimation of subjects' responses after dropout using data prior to the dropout. [...] they use all the data and can reduce bias due to dropout. Because of the flexibility allowed, careful consideration should be given to planning what model to fit, what hypotheses to test, and how to describe the interrelationship of values over time.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Commentary-1
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ISSN:0002-953X
1535-7228
1535-7228
DOI:10.1176/appi.ajp.2009.09040458