Self-Delivery Photo-Immune Stimulators for Photodynamic Sensitized Tumor Immunotherapy

• Published in: ACS nano Vol. 14; no. 12; pp. 17100 - 17113
• Main Authors: Zhao, Lin-Ping, Zheng, Rong-Rong, Huang, Jia-Qi, Chen, Xia-Yun, Deng, Fu-An, Liu, Yi-Bin, Huang, Chu-Yu, Yu, Xi-Yong, Cheng, Hong, Li, Shi-Ying
• Format: Journal Article
• Language: English
• Published: American Chemical Society 22.12.2020
• Subjects: self-delivery; immunogenetic cell death; nanomedicine; tumor immunotherapy; photodynamic therapy
• ISSN: 1936-0851; 1936-086X; 1936-086X
• DOI: 10.1021/acsnano.0c06765

Self-delivery of photosensitizer and immune modulator to tumor site is highly recommendable to improve the photodynamic immunotherapy yet remains challenging. Herein, self-delivery photoimmune stimulators (designated as iPSs) are developed for photodynamic sensitized tumor immunotherapy. Carrier-free iPSs are constructed by optimizing the noncovalent interactions between the pure drugs of chlorine e6 (Ce6) and NLG919, which avoid the excipients-raised toxicity and immunogenicity. Intravenously administrated iPSs prefer to passively accumulate on tumor tissues for a robust photodynamic therapy (PDT) with the induction of immunogenetic cell death (ICD) cascade to activate cytotoxic T lymphocytes (CTLs) and initiate antitumor immune response. Meanwhile, the concomitant delivery of NLG919 inhibits the activation of indoleamine 2,3-dioxygenase 1 (IDO-1) to reverse the immunosuppressive tumor microenvironment. Ultimately, the photodynamic sensitized immunotherapy with iPSs efficiently inhibit the primary and distant tumor growth with a low system toxicity, which would shed light on the development of self-delivery nanomedicine for clinical transformation in tumor precision therapy.