A Safer, Discovery-Based Nucleophilic Substitution Experiment

A discovery-based nucleophilic substitution experiment is described in which students compare the reactivity of chloride and iodide ions in an SN2 reaction. This experiment improves upon the well-known "Competing Nucleophiles" experiment in that it does not involve the generation of hydrog...

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Bibliographic Details
Published inJournal of chemical education Vol. 86; no. 3; pp. 363 - 364
Main Author Horowitz, Gail
Format Journal Article
LanguageEnglish
Published Easton Division of Chemical Education 01.03.2009
Division of Chemical Education of the American Chemical Society
American Chemical Society
Subjects
Chemical reactions
Chemistry
College Science
College students
Experiments
Laboratory Experiments
Organic chemistry
Science education
Science Experiments
Science Instruction
Science Laboratories
Scientific Principles
Students
Substitution reactions
Substrates
Undergraduate Study
Second-Year Undergraduate
Inquiry-Based / Discovery Learning
Catalysis
Laboratory Instruction
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Summary:A discovery-based nucleophilic substitution experiment is described in which students compare the reactivity of chloride and iodide ions in an SN2 reaction. This experiment improves upon the well-known "Competing Nucleophiles" experiment in that it does not involve the generation of hydrogen halide gas. The experiment also introduces students to the subject of phase-transfer catalysis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:0021-9584
1938-1328
DOI:10.1021/ed086p363