A Study on the Use of Phase Transition Lysozyme-Loaded Minocycline Hydrochloride in the Local Treatment of Chronic Periodontitis

• Published in: ACS applied bio materials Vol. 5; no. 7; pp. 3146 - 3157
• Main Authors: Wang, Yao, Deng, Jingjing, Zhang, Tingting, Hua, Ye, Wang, Yuanyuan, Zhang, Qian, Jiao, Tiejun, Li, Changyi, Zhang, Xu
• Format: Journal Article
• Language: English
• Published: American Chemical Society 18.07.2022
• Subjects: antibacterial activity; periodontal tissue regeneration; sustained release; minocycline hydrochloride; phase transition lysozyme
• ISSN: 2576-6422; 2576-6422
• DOI: 10.1021/acsabm.2c00079

Periodontitis is the most important oral disease causing human tooth loss. Although supragingival and subgingival scaling is the main strategy of periodontitis clinical treatments, drug treatment has an indispensable auxiliary role to some degree. Periodontitis medical treatment is divided into systemically administered treatments and local periodontally administered treatments. Compared with systemic administration, local administration can increase local drug concentrations, reduce dosages, and prolong action times while also improving patient compliance and avoiding possible adverse effects due to systemic administration responses. However, some studies show that minocycline ointment, a clinical local drug commonly used in periodontal pockets, has an unstable release rate; 80% of the drug is usually released within 2–3 days after pocket placement. This release is not conducive to controlling periodontal infection and may hinder the periodontal tissue repair and regeneration. Therefore, choosing a suitable carrier for minocycline hydrochloride is necessary to control its local release in periodontal tissue. Phase transition lysozyme (PTL) has been widely used in many studies and the development of macromolecular carrier material, and we selected PTL as the carrier for minocycline hydrochloride drugs because of its good biocompatibility, good drug-carrying capacity, and stable release. Due to its release characteristics and simple preparation, PTL is a promising carrier material.