Bifunctional Organocatalysts for the Enantioselective Synthesis of Axially Chiral Isoquinoline N‑Oxides

• Published in: Journal of the American Chemical Society Vol. 137; no. 21; pp. 6766 - 6769
• Main Authors: Miyaji, Ryota, Asano, Keisuke, Matsubara, Seijiro
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 03.06.2015

Bifunctional catalysts bearing amino and urea functional groups have been applied for a novel, highly enantioselective synthesis of axially chiral isoquinoline N-oxides, which are promising chiral ligands or organocatalysts in organic synthesis. This is the first example of highly enantioselective s...