Bifunctional Organocatalysts for the Enantioselective Synthesis of Axially Chiral Isoquinoline N‑Oxides

Bifunctional catalysts bearing amino and urea functional groups have been applied for a novel, highly enantioselective synthesis of axially chiral isoquinoline N-oxides, which are promising chiral ligands or organocatalysts in organic synthesis. This is the first example of highly enantioselective s...

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Published inJournal of the American Chemical Society Vol. 137; no. 21; pp. 6766 - 6769
Main Authors Miyaji, Ryota, Asano, Keisuke, Matsubara, Seijiro
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 03.06.2015
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Summary:Bifunctional catalysts bearing amino and urea functional groups have been applied for a novel, highly enantioselective synthesis of axially chiral isoquinoline N-oxides, which are promising chiral ligands or organocatalysts in organic synthesis. This is the first example of highly enantioselective synthesis of axially chiral biaryls by bifunctional organocatalysts. Good-to-excellent enantioselectivities were obtained with a range of substrates.
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ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.5b04151