Manganese Catalyzed Hydrogenation of Enantiomerically Pure Esters

A manganese-catalyzed hydrogenation of esters has been accomplished with TONs up to 1000, using cheap, environmentally benign, potassium carbonate and simple alcohols as activator and solvent, respectively. The weakly basic conditions lead to good functional group tolerance and enable the hydrogenat...

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Bibliographic Details
Published inOrganic letters Vol. 20; no. 9; pp. 2654 - 2658
Main Authors Widegren, Magnus B, Clarke, Matthew L
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 04.05.2018
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Summary:A manganese-catalyzed hydrogenation of esters has been accomplished with TONs up to 1000, using cheap, environmentally benign, potassium carbonate and simple alcohols as activator and solvent, respectively. The weakly basic conditions lead to good functional group tolerance and enable the hydrogenation of enantiomerically enriched α-chiral esters with essentially no loss of stereochemical integrity.
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b00864