Efficient C−H/C−D Exchange Reaction on the Alkyl Side Chain of Aromatic Compounds Using Heterogeneous Pd/C in D2O

An efficient and extensive deuterium incorporation using heterogeneous Pd/C−D2O−H2 system into many different types of unactivated C−H bond positions was developed. The present method provides a deuterium gas-free, totally catalytic, and post-synthetic deuterium labeling method in D2O media.

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Bibliographic Details
Published inOrganic letters Vol. 6; no. 9; pp. 1485 - 1487
Main Authors Sajiki, Hironao, Aoki, Fumiyo, Esaki, Hiroyoshi, Maegawa, Tomohiro, Hirota, Kosaku
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 29.04.2004
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Summary:An efficient and extensive deuterium incorporation using heterogeneous Pd/C−D2O−H2 system into many different types of unactivated C−H bond positions was developed. The present method provides a deuterium gas-free, totally catalytic, and post-synthetic deuterium labeling method in D2O media.
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol0496374