Phenytoin and Carbamazepine in Production of Cleft Palates in Mice: Comparison of Teratogenic Effects

• The teratogenic activity of two anticonvulsant drugs, phenytoin sodium and carbamazepine, was studied in pregnant mice fed phenytoin and carbamazepine during days 8 to 13. Incidence of palatal defects and other abnormalities correlated with increasing dosages and blood levels of the drugs. Phenyto...

Full description

Saved in:
Bibliographic Details
Published inArchives of neurology (Chicago) Vol. 36; no. 13; pp. 832 - 836
Main Authors Paulson, Ruta B, Paulson, George W, Jreissaty, Salim
Format Journal Article
LanguageEnglish
Published United States American Medical Association 01.12.1979
Subjects
Animals
Carbamazepine - adverse effects
Carbamazepine - blood
Cleft Palate - chemically induced
Cleft Palate - embryology
Dose-Response Relationship, Drug
Female
Mice
Phenytoin - adverse effects
Phenytoin - blood
Pregnancy
Online AccessGet full text

Cover

More Information
Summary:• The teratogenic activity of two anticonvulsant drugs, phenytoin sodium and carbamazepine, was studied in pregnant mice fed phenytoin and carbamazepine during days 8 to 13. Incidence of palatal defects and other abnormalities correlated with increasing dosages and blood levels of the drugs. Phenytoin produced a much higher incidence of teratogenic effects than carbamazepine.
ISSN:0003-9942
1538-3687
DOI:10.1001/archneur.1979.00500490046007