Visual Biosensing with Specific Liquid-Based Interface Behaviors

• Published in: ACS nano Vol. 18; no. 10; pp. 7327 - 7333
• Main Authors: Wang, Huimeng, Fan, Yi, Wang, Hui, Chen, Zemin, Yu, Shijie, Hou, Xu
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 12.03.2024
• ISSN: 1936-0851; 1936-086X
• DOI: 10.1021/acsnano.3c08396

Liquid-based interface behaviors at micro/nano or even smaller scales induced by biomolecules take us into a fascinating realm, fostering a deeper understanding and innovation in visual biosensing. This biosensing technology, grounded in specific liquid-based interface behaviors, redefines how diseases can be detected, monitored, and diagnosed in resource-limited settings, providing rapid, cost-effective, and self-testing solutions to the current healthcare landscape. To date, the technology has witnessed significant advancements in visual sensing, driven by diverse liquid-based materials, advanced nanomanufacturing techniques, and a profound understanding of interface–material interactions. In this Perspective, we discuss and elucidate the interface biosensing mechanisms arising from three types, including liquid–solid, liquid–liquid, and liquid–gas interfaces, and we provide insights into the challenges and future development of visual biosensing applications.