Manganese-Catalyzed C(α)-Alkylation of Oxindoles with Secondary Alcohols via Borrowing Hydrogen

A general and efficient C­(α)-alkylation of oxindoles with unactivated secondary alcohols as alkylating agents catalyzed by a newly developed NNN-Mn­(II) complex is reported. Mechanistic studies illustrate that the importance of the NH moiety in the complex and M–L cooperation play very important ro...

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Published inOrganometallics Vol. 40; no. 6; pp. 627 - 634
Main Authors Rana, Jagannath, Nagarasu, Palaniyappan, Subaramanian, Murugan, Mondal, Akash, Madhu, Vedichi, Balaraman, Ekambaram
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 22.03.2021
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Physical Sciences
Science & Technology
ALPHA-ALKYLATION
C-ALKYLATION
AMINES
STRATEGY
ESTERS
AMIDES
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Summary:A general and efficient C­(α)-alkylation of oxindoles with unactivated secondary alcohols as alkylating agents catalyzed by a newly developed NNN-Mn­(II) complex is reported. Mechanistic studies illustrate that the importance of the NH moiety in the complex and M–L cooperation play very important roles during the catalytic transformation.
ISSN:0276-7333
1520-6041
DOI:10.1021/acs.organomet.1c00009