Multigram Laboratory Scale Synthesis of α‑Trifluoromethoxy Carbonyl Compounds

α-trifluoromethoxy carbonyl compounds are valuable building blocks for the synthesis of various trifluoromethoxylated compounds. The best way to easily obtain them is the direct trifluoromethoxylation with the CF3O– anion, generated in situ from trifluoromethyl triflate. However, the necessary autog...

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Bibliographic Details
Published inOrganic process research & development Vol. 18; no. 8; pp. 1037 - 1040
Main Authors Barbion, Julien, Pazenok, Sergii, Vors, Jean-Pierre, Langlois, Bernard R, Billard, Thierry
Format Journal Article
LanguageEnglish
Published American Chemical Society 15.08.2014
Subjects
Chemical Sciences
Organic chemistry
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Summary:α-trifluoromethoxy carbonyl compounds are valuable building blocks for the synthesis of various trifluoromethoxylated compounds. The best way to easily obtain them is the direct trifluoromethoxylation with the CF3O– anion, generated in situ from trifluoromethyl triflate. However, the necessary autogenous pressure generated during this reaction constitutes a main drawback for a multigram scale extrapolation. A specific procedure using adapted glassware has allowed a laboratory large-scale production (up to 50 g) of such building blocks with good yields.
ISSN:1083-6160
1520-586X
DOI:10.1021/op500118r