Synthetic Studies toward FR182877. Remarkable Solvent Effect in the Vinylogous Morita−Baylis−Hillman Cyclization

The intramolecular vinylogous Morita−Baylis−Hillman reaction was explored to access the central cyclopentane ring of FR182877. The reaction manifold and product distribution is strikingly solvent and substrate dependent.

Saved in:
Bibliographic Details
Published inOrganic letters Vol. 5; no. 22; pp. 4223 - 4226
Main Authors Methot, Joey L, Roush, William R
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 30.10.2003
Subjects
Catalysis
Cyclization
Molecular Conformation
Molecular Structure
Organotin Compounds - chemistry
Phosphines - chemistry
Polycyclic Compounds - chemical synthesis
Polycyclic Compounds - chemistry
Solvents - chemistry
Online AccessGet full text

Cover

More Information
Summary:The intramolecular vinylogous Morita−Baylis−Hillman reaction was explored to access the central cyclopentane ring of FR182877. The reaction manifold and product distribution is strikingly solvent and substrate dependent.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0357550