Solubility of Indinavir Sulfate in Different Solvents from (278.35 to 314.15) K

The solubility of indinavir sulfate in ethanol, 1-propanol, 2-propanol, 1-butanol, and 2-methyl-1-propanol was measured over the temperature range of (278.35 to 314.15) K under atmospheric pressure. The experimental data were correlated by the modified Apelblat model. The results show that the solub...

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Bibliographic Details
Published inJournal of chemical and engineering data Vol. 54; no. 7; pp. 2106 - 2108
Main Authors Hou, Guangyang, Yin, Qiuxiang, Zhang, Meijing, Su, Weiyi, Mao, Huilin, Wang, Jingkang
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 09.07.2009
Subjects
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
Medical sciences
Pharmacology. Drug treatments
Peptidases
Organic solvent
Enzyme
Peptidomimetic compound
Solubility
Enzyme inhibitor
Hydrolases
Antiviral
Sulfates
Protease inhibitor
Indinavir
Physicochemical properties
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Summary:The solubility of indinavir sulfate in ethanol, 1-propanol, 2-propanol, 1-butanol, and 2-methyl-1-propanol was measured over the temperature range of (278.35 to 314.15) K under atmospheric pressure. The experimental data were correlated by the modified Apelblat model. The results show that the solubility of indinavir sulfate in the selected solvents increased with increasing temperature.
ISSN:0021-9568
1520-5134
DOI:10.1021/je800689a