Tracing a Common “Origin” of Phase Transformation, Polymorphism, Disorder, Isosterism, and Isostructuralism in Fluorobenzoylcarvacryl Thiourea

• Published in: Crystal growth & design Vol. 12; no. 9; pp. 4530 - 4534
• Main Authors: Dikundwar, Amol G, Pete, Umesh D, Zade, Chetan M, Bendre, Ratnamala S, Guru Row, Tayur N
• Format: Journal Article
• Language: English
• Published: Washington,DC American Chemical Society 05.09.2012
• Subjects: Condensed matter: structure, mechanical and thermal properties; Constant-composition solid-solid phase transformations: polymorphic, massive, and order-disorder; Cross-disciplinary physics: materials science; rheology; Crystalline state (including molecular motions in solids); Crystallographic aspects of phase transformations; pressure effects; Exact sciences and technology; Materials science; Phase diagrams and microstructures developed by solidification and solid-solid phase transformations; Physics; Structure of solids and liquids; crystallography; Structure of specific crystalline solids; Design engineering; Hydrogen bonds; Phase transformations; Molecular crystals; Thiourea; Chemical synthesis; Thioureas; Polymorphism; Crystal structure; Synthon
• ISSN: 1528-7483; 1528-7505
• DOI: 10.1021/cg300699r

The terms phase transformation, polymorphism, disorder, isosterism, and isostructuralism are often the keywords used in the design and engineering of molecular crystals. Three benzoylcarvacryl thiourea derivatives with [-NH–C(S)–NH–C(O)-] cores generate molecular crystals, which provide the basis for exploring a common link between the structures related by aforementioned terms. The apparent “origin” of all these structural modifications has been traced to the formation of a planar molecular dimeric chain built with homomeric R2 2(12) and R2 2(8) synthons occurring in tandem, one formed with N–H···O and the other with N–H···S hydrogen bonds.