Short-Cut Method To Predict the Solubility of Organic Molecules in Aqueous and Nonaqueous Solutions by Differential Scanning Calorimetry

• Published in: Crystal growth & design Vol. 6; no. 1; pp. 313 - 320
• Main Authors: Tamagawa, Rosana E, Martins, Wilson, Derenzo, Silas, Bernardo, André, Rolemberg, Marlus P, Carvan, Phillipe, Giulietti, Marco
• Format: Journal Article
• Language: English
• Published: Washington,DC American Chemical Society 01.01.2006
• Subjects: Condensed matter: structure, mechanical and thermal properties; Cross-disciplinary physics: materials science; rheology; Equations of state, phase equilibria, and phase transitions; Exact sciences and technology; Materials science; Materials testing; Physics; Solubility, segregation, and mixing; phase separation; Thermal analysis, differential thermal analysis (DTA), differential thermogravimetric analysis; Organic solution; Differential scanning calorimetry; Aqueous solutions; Enthalpy; Digital simulation; Solubility; Heat capacity; Alcoholic solution; Experimental study; Dissolution; Organic compounds
• ISSN: 1528-7483; 1528-7505
• DOI: 10.1021/cg050128y

According to recent literature, − differential scanning calorimetry (DSC) is being proposed as an alternative technique for the determination of solubility curves with the advantage of requiring a small quantity of sample (in the order of milligrams), besides being a fast method:  solubility data can be accessed in a few hours. In this work, DSC was applied for estimating the solubility of organic molecules in aqueous and nonaqueous solutions. The method was carried out using four organic substances, referred to here as substances A, B, C, and D, A and B being solubilized in water, C in a mixture of methanol−water 20 wt %, and D in acetone.