Asymmetric Brominative Dearomatization of 2‑Naphthols Using a Cinchona Alkaloid-Based Organocatalyst

A cinchona alkaloid-based organocatalyst enables asymmetric brominative dearomatization of 2-naphthols, providing the corresponding bromonaphthalenones with high enantioselectivities. The first metal-free reaction can accommodate a variety of functional groups and give useful frameworks bearing a Br...

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Bibliographic Details
Published inJournal of organic chemistry Vol. 89; no. 6; pp. 4232 - 4236
Main Authors Omae, Kouhei, Miyake, Yoshihiro, Shimogaki, Mio
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 15.03.2024
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Summary:A cinchona alkaloid-based organocatalyst enables asymmetric brominative dearomatization of 2-naphthols, providing the corresponding bromonaphthalenones with high enantioselectivities. The first metal-free reaction can accommodate a variety of functional groups and give useful frameworks bearing a Br-containing tetrasubstituted stereogenic center.
Bibliography:ObjectType-Article-1
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ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.3c02945