Layered Double Hydroxide (LDH)-Based Nanotripod for High-Entropydynamic Therapy Associated with Metabolism Homeostasis

• Published in: ACS applied bio materials Vol. 8; no. 1; pp. 903 - 912
• Main Authors: Song, Kai, Yang, Xueting, Ren, Yingying, Mo, Zheng, Fei, Yu, Gu, Xiangling, Xiao, Shizhuo, Sun, Chenghua, Guan, Shanyue, Bao, Pengtao, Qu, Xiaozhong
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 20.01.2025
• Subjects: Animals; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Biocompatible Materials - chemical synthesis; Biocompatible Materials - chemistry; Biocompatible Materials - pharmacology; Cell Proliferation - drug effects; Drug Screening Assays, Antitumor; Homeostasis - drug effects; Humans; Hydroxides - chemistry; Hydroxides - pharmacology; Materials Testing; Mice; Particle Size; Reactive Oxygen Species - metabolism; Surface Properties; NADH; high-entropydynamic therapy; MRI; nanotripod; high-entropy oxides
• ISSN: 2576-6422; 2576-6422
• DOI: 10.1021/acsabm.4c01745

Multielemental transition metal compounds represent a class of promising candidates for the biomedical field due to their unique structure and biomedical application potential. However, their synthesis process remains challenging, which was subject to the high-temperature treatment of the multimetallic elements integrated within one system. Herein, for the first time, we have fabricated the nanotripod, i.e., (FeCoNiCuZnAl)­O x (denoted as HEO) agent, via the structural topotactic transformation of layered double hydroxide (LDH) precursors with the tunable disorder degree, for highly efficient high-entropydynamic therapy associated with metabolism homeostasis. By virtue of this unique high-entropy structure, the outburst reactive oxygen species (ROS) generation can be regulated via turbulence. These unique high-entropy oxides not only presented outstanding ROS generation efficiency but also broke the intracellular metabolic balance cycle (NADH/NAD+) by NO x -like activity, which can disturb the tumor energy metabolism homeostasis, leading to cell apoptosis. Furthermore, in vitro and in vivo experiments both indicate that this agent was a satisfying candidate for magnetic resonance imaging (MRI)-guided therapy. The findings offer a strategy for the development of high-entropydynamic therapy.