Overview of Recent Scale-Ups in Organic Electrosynthesis (2000–2023)

This review summarizes examples of organic electrosynthesis from the peer-reviewed literature from 2000 to 2023 that have been conducted on scales of 20 g or above. A significant portion of these examples were conducted on a ≤100 g scale, while detailed reports of kilogram-scale electrosynthesis rem...

Full description

Saved in:
Bibliographic Details
Published inOrganic process research & development Vol. 28; no. 2; pp. 338 - 366
Main Authors Lehnherr, Dan, Chen, Longrui
Format Journal Article
LanguageEnglish
Published American Chemical Society 16.02.2024
Subjects
process chemistry
kilogram scale
electrochemistry
electrosynthesis
scale up
flow chemistry
Online AccessGet full text
ISSN1083-6160
1520-586X
DOI10.1021/acs.oprd.3c00340

Cover

More Information
Summary:This review summarizes examples of organic electrosynthesis from the peer-reviewed literature from 2000 to 2023 that have been conducted on scales of 20 g or above. A significant portion of these examples were conducted on a ≤100 g scale, while detailed reports of kilogram-scale electrosynthesis remain scarce in the pharmaceutical industry. In addition to the chemical transformation, this review also highlights the type of reactor used and a projected productivity metric as ways to compare the different reports. The selected examples of organic electrosynthesis scale-ups described herein also illustrate the remaining challenges currently preventing the routine use of large-scale electrosynthesis in the pharmaceutical industry.
ISSN:1083-6160
1520-586X
DOI:10.1021/acs.oprd.3c00340