Manganese-Catalyzed Alkoxycarbonylation of Alkyl Chlorides

The carbonylative transformation of alkyl chlorides, a class of cheap chemical feedstock, is among the most challenging tasks in the field of carbonylation due to the difficulty of C­(sp3)–Cl bond activation. Herein, we report the catalytic alkoxycarbonylation of unactivated alkyl chlorides. This me...

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Bibliographic Details
Published inACS catalysis Vol. 13; no. 2; pp. 1310 - 1315
Main Authors Ai, Han-Jun, Geng, Hui-Qing, Gu, Xing-Wei, Wu, Xiao-Feng
Format Journal Article
LanguageEnglish
Published American Chemical Society 20.01.2023
Subjects
manganese catalyst
alkoxycarbonylation
alkyl chlorides
carbonylation
ester
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Summary:The carbonylative transformation of alkyl chlorides, a class of cheap chemical feedstock, is among the most challenging tasks in the field of carbonylation due to the difficulty of C­(sp3)–Cl bond activation. Herein, we report the catalytic alkoxycarbonylation of unactivated alkyl chlorides. This method employs a pincer manganese catalyst to overcome the intrinsic limitations of C­(sp3)–Cl bond activation and allows access to various esters in a straightforward manner. Mechanistic studies indicate that the alkyl chlorides were activated directly via an oxidative addition reaction.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.2c05854