Successful high-dose intravenous cytarabine treatment of parenchymal brain involvement from malignant lymphoma

A patient with systemic recurrence of large-cell malignant lymphoma developed radiologic evidence of parenchymal brain metastasis. Treatment with systemic high-dose cytarabine resulted in complete regression of peripheral adenopathy and complete radiologic response in the central nervous system, wit...

Full description

Saved in:
Bibliographic Details
Published inArchives of internal medicine (1960) Vol. 146; no. 4; p. 791
Main Authors Frick, J C, Hansen, R M, Anderson, T, Ritch, P S
Format Journal Article
LanguageEnglish
Published United States 01.04.1986
Subjects
Brain Neoplasms - drug therapy
Brain Neoplasms - secondary
Corpus Callosum
Cytarabine - administration & dosage
Cytarabine - therapeutic use
Female
Frontal Lobe
Humans
Infusions, Parenteral
Lymphoma - drug therapy
Lymphoma - secondary
Middle Aged
Spinal Neoplasms
Online AccessGet more information

Cover

More Information
Summary:A patient with systemic recurrence of large-cell malignant lymphoma developed radiologic evidence of parenchymal brain metastasis. Treatment with systemic high-dose cytarabine resulted in complete regression of peripheral adenopathy and complete radiologic response in the central nervous system, with normalization of the brain computed tomographic scan. This case further demonstrates the ability of high-dose cytarabine to penetrate the blood-brain barrier and achieve therapeutic drug concentrations in the central nervous system, an area that might otherwise remain a pharmacologic sanctuary for tumor cells.
ISSN:0003-9926
DOI:10.1001/archinte.1986.00360160243032